Prenatal exposure to low doses of fungicides corrupts neurogenesis in neonates

Neurogenesis plays a crucial role during neurodevelopment and its dysfunction can lead to neurodevelopmental disorders. A recent hypothesis stipulates that exogenous factors could corrupt this process predispose neurodegenerative disorders later in life. The presence of pesticide residues the diet represents threat which we have recently become aware of. Indeed, they neurogenesis, especially gestation, potentially leading impaired neuronal synaptic functions. Since effects low-noise contamination not yet been evaluated on neurodevelopment, investigated impact fungicide WT mice exposed throughout gestation. Thus, were fungicides, cyprodinil, mepanipyrim pyrimethanil, alone at 0.1 ?g/L gestation until P3. Besides, another group was cocktail these three fungicides (0.1 each) for same time. Exposure performed through drinking water regulatory limit dose European countries ?g/L). No general toxicity observed neonates body brain weight upon exposure. However, results showed gestational exposure substantially promoted an increase neural precursor cells This corrupted neurogenesis linked increased levels ?-catenin, likely crosstalk PI3K/Akt Wnt/?-catenin pathways, both involved cell proliferation. Fungicide also altered protein expression PSD95 NMDA receptors P3 neonates, two targets ?-catenin signaling pathway. Adult stem extractions from treated with cocktail, proliferation differentiation combined reduction their migration properties. In addition, vitro studies hippocampal primary cultures various concentrations neurotoxic effects. To conclude, corruption by chemical assault be fertile ground development neurological diseases